Abstract

            In this seminar, we review the importance of chromatographic selectivity in HPLC from a theoretical and practical perspective and how this relates to analyte resolution for method development.  With an understanding of selectivity, and using a variety of chromatographic data, we discuss phase design principles and how it is possible to introduce functionality to enhance selectivity through mechanisms such as hydrophobicity, π-π, dipole-dipole and shape selectivity interactions.  An overview of the method development workflow is discussed.  Based upon the key parameters to maximise selectivity, a systematic and optimised method development screening platform is described and an example related substances method development activity is illustrated using the complementary stationary phases with Methanol and Acetonitrile solvents.

Learning objective

          To empower research and quality control efficiency in selection of chromatography methods for drug analysis, complying with international guidelines and allowing identification of potential contaminants.

Target audience :   R&D, QC in Pharmaceutical sectors

Speaker :

Gemma Lo

Global Product Management Lead : Proprietary Chromatography Consumables & High Purity Solvents

       Avantorscience.Co.Ltd   

Registration : free of charge

รหัสกิจกรรม

2004-2-000-002-02-2568

Pharmacist who attends the webinar and passes the quiz will obtain 2 cpe