ลงทะเบียนประชุมวิชาการ
Overview:
Liquid chromatography-mass
spectrometry (LC-MS) is a vital tool for analytical characterization and
bioprocess development support. However there are two critical bottlenecks to
its implementation into the respective workflows: the complexity of the crude
bioprocess samples and the perceived difficulty in mastering the LC-MS analysis.
We address these two questions in this two-part seminar. In the first part, we present a streamlined LC-MS platform that serves
two critical purposes for bioprocesses: biosimilar comparative assessment and
bioprocess analytical development. In the second part, we pivot the very same LC-MS
platform to monitoring critical quality attributes (CQA) of sgRNA and mRNA for
product quality and process consistency, and how these MS-based RNA analysis is
made accessible to biologics experts.
Learning Objectives
·
Simplified LC-MS acquisition using BioAccord™
LC-MS System, a benchtop TOF MS designed for ease of operation for analysts of
all levels of expertise
·
Utilization of the waters_connect™ Intact Mass
App for streamlined automated data acquisition and analysis with
compliance-ready features to ensure data integrity
·
Automated ProA purification for biosimilar
subunit analysis
·
Biosimilar CQAs analysis (Fab vs Fc
modifications, orthogonality between mab subunit workflow and released N-glycan
assays)
·
RNA CQAs analysis (sgRNA, mRNA and RNA digest
fragment mapping)
Agenda:
§ 09.00 – 09.30: Registration
§ 09.30– 10.15:
Streamlined LC-MS Platform for Biosimilar Comparative Assessment and Bioprocess
Analytical Development (Speaker:
Terence)
§ 10.15 – 10.25:
Waters Commercial Video Break
§ 10.25 - 11.20:
LC-MS for RNA Therapeutics to Ensure Product Quality and Process Consistency
(Speaker: YanTing)
§ 11.20 – 11.30:
Q&A
Who is for It?
ü
Scientists, Technicians and Managers, who are
charged with bioprocess analytics and analyzing therapeutic RNA samples.
ü
Others from pharmaceutical and contract
organizations looking towards developing and commercializing these molecules,
who want to better understand the analytical challenges of producing high
quality products and processes.
เภสัชกรที่เข้าฟังสัมมนาและผ่านการทดสอบ จะได้รับ 2.0 หน่วยกิตการศึกษาต่อเนื่อง
รหัสกิจกรรม | ![]() | 2004-2-000-013-07-2567 |
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